探花直播 of Cambridge - Downing College /taxonomy/affiliations/downing-college News from Downing College. en Complete clean sweep for Cambridge at 探花直播Boat Race 2025 /news/complete-clean-sweep-for-cambridge-at-the-boat-race-2025 <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/news/podium.jpg?itok=zt6jwQr7" alt="" title="Credit: Row360" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Thousands of spectators lined the banks of the River Thames on 13 April to witness a dramatic afternoon of action, with millions more following live on the BBC.</p> <p>Cambridge Women secured their eighth consecutive win in the 79th Women鈥檚 Boat Race, extending their overall record to 49 victories to Oxford鈥檚 30. 探花直播Men鈥檚 crew, too, were victorious in defending their title in the 170th edition of the event, notching up their 88th win, with Oxford sitting on 81.</p> <p>Goldie, the Cambridge Men鈥檚 Reserve Crew, won the Men鈥檚 Reserve Race, while Blondie, the Cambridge Women鈥檚 Reserve Crew, won the Women鈥檚 Reserve Race. And the day before, the 2025 Lightweight Boat Race also saw two wins for Cambridge.</p> <p>Cambridge鈥檚 Claire Collins said it was an incredible feeling to win the race.聽</p> <p>鈥淭his is so cool, it鈥檚 really an incredible honour to share this with the whole club,鈥 she said.</p> <p> 探花直播Women鈥檚 Race was stopped initially after an oar clash, but Umpire Sir Matthew Pinsent allowed the race to resume after a restart. Claire said that the crew had prepared for eventualities such as a restart and so were able to lean on their training when it happened.</p> <p>鈥淚 had total confidence in the crew to regroup. Our focus was to get back on pace and get going as soon as possible and that鈥檚 what we did.鈥</p> <p>For Cambridge Men鈥檚 President Luca Ferraro, it was his final Boat Roat campaign, having raced in the Blue Boat for the last three years, winning the last two.</p> <p>He said: 鈥淚t was a great race. 探花直播guys really stepped up. That鈥檚 something that our Coach Rob Baker said to us before we went out there, that each of us had to step up individually and come together and play our part in what we were about to do. I couldn鈥檛 be prouder of the guys, they really delivered today.鈥</p> <p>Professor Deborah Prentice, Vice-Chancellor of the 探花直播 of Cambridge, congratulated all the crews following the wins.</p> <p>鈥淚 am in awe of these students and what they have achieved, and what Cambridge 探花直播 Boat Club has been able to create,鈥 she said.</p> <p>鈥淭hese students are out in the early hours of the morning training and then trying to make it to 9am lectures. It鈥檚 so inspiring. And a complete clean sweep 鈥 this was an incredibly impressive showing by Cambridge, I am so proud of them.鈥</p> <p> 探花直播Cambridge Blue Boats featured student athletes drawn from Christ鈥檚 College, Downing College, Emmanuel College, Gonville &amp; Caius, Hughes Hall, Jesus College, Pembroke College, Peterhouse, St Edmund鈥檚, and St John鈥檚.</p> </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>Cambridge is celebrating a complete clean sweep at 探花直播Boat Race 2025, with victories in all 4聽openweight races and also both lightweight races.</p> </p></div></div></div><div class="field field-name-field-image-credit field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://row-360.com/" target="_blank">Row360</a></div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img alt="Creative Commons License." src="/sites/www.cam.ac.uk/files/inner-images/cc-by-nc-sa-4-license.png" style="border-width: 0px; width: 88px; height: 31px;" /></a><br /> 探花直播text in this work is licensed under a <a href="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways 鈥 on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p> </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Sun, 13 Apr 2025 15:34:14 +0000 hcf38 249321 at Cambridge Blue Boats revealed for 探花直播Boat Race 2025 /news/cambridge-blue-boats-revealed-for-the-boat-race-2025 <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/news/bt1-1364-6-landscape.jpg?itok=2yamPOj9" alt=" 探花直播Boat Race 2025 crews outside Battersea Power Station, London." title="Credit: Row360" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>With just over 2聽weeks to go until the showdown on the River Thames, the Light Blues are gearing up to defend their titles. Cambridge leads the historic tally in both the men鈥檚 and women鈥檚 events and will be looking to extend their dominance when they take on Oxford on Sunday 13 April 2025.</p> <h2>Cambridge Crews for 探花直播Boat Race 2025</h2> <p>Women鈥檚 Blue Boat:<br /> 鈥⒙犅 聽Cox: Jack Nicholas (Pembroke College)<br /> 鈥⒙犅 聽Stroke: Samy Morton (Hughes Hall)<br /> 鈥⒙犅 聽Tash Morrice (Jesus College)<br /> 鈥⒙犅 聽Claire Collins (Peterhouse)<br /> 鈥⒙犅 聽Carys Earl (Gonville &amp; Caius)<br /> 鈥⒙犅 聽Annie Wertheimer (St Edmund鈥檚 College)<br /> 鈥⒙犅 聽Sophia Hahn (Hughes Hall)<br /> 鈥⒙犅 聽Gemma King (St John鈥檚 College)<br /> 鈥⒙犅 聽Bow: Katy Hempson (Christ鈥檚 College)</p> <p><br /> Men鈥檚 Blue Boat:<br /> 鈥⒙犅 聽Cox: Ollie Boyne (Downing College)<br /> 鈥⒙犅 聽Stroke: Douwe de Graaf (St Edmund鈥檚)<br /> 鈥⒙犅 聽Luca Ferraro (Peterhouse)<br /> 鈥⒙犅 聽James Robson (Peterhouse)<br /> 鈥⒙犅 聽George Bourne (Peterhouse)<br /> 鈥⒙犅 聽Gabriel Mahler (Peterhouse)<br /> 鈥⒙犅 聽Tom Macky (St Edmund鈥檚)<br /> 鈥⒙犅 聽Noam Mouelle (Hughes Hall)<br /> 鈥⒙犅 聽Bow: Simon Hatcher (Peterhouse)</p> <p><strong>Countdown to 探花直播Boat Race 2025</strong><br /> 探花直播prestigious race, one of the oldest amateur sporting events in the world, will take place along the 6.8 km Championship Course from Putney to Mortlake. 探花直播Women's Boat Race will commence at 1:21pm British Summer Time (BST), followed by the Men's Boat Race at 2:21pm BST.</p> <p>Cambridge鈥檚 women鈥檚 crew enters the race as the defending champions and currently leads the overall tally at 48-30. Meanwhile, Cambridge鈥檚 men鈥檚 crew also holds the advantage, leading Oxford 87-81, with one historic dead heat in 1877.</p> <h2>Praise for the athletes</h2> <p>Siobhan Cassidy, Chair of 探花直播Boat Race Company, congratulated the athletes on their selection for one of the Blue Boats. 鈥淚 am not sure that everyone appreciates just what it takes to compete at this level,鈥 she told the event.</p> <p>鈥淗aving witnessed the intense training over a number of years, I can tell you these guys are no ordinary students; they combine their academic courses with a high-performance rowing programme. Their commitment to excellence on and off the water is truly extraordinary. It is nothing short of superhuman.鈥</p> <p>Renowned BBC Sport commentator Andrew Cotter, who hosted the event, emphasised the purity of 探花直播Boat Race in today鈥檚 sporting landscape. 鈥淚n the modern era of sport, when so much is inflated by money and professionalism, this is sport stripped back to its essence,鈥 he said.聽</p> <p>鈥淚t is pure competition, it is about winning and losing. And I know that鈥檚 how the athletes feel about it, but they also feel that this is where they will make friendships that will last a lifetime.鈥</p> <h2>Historic firsts and environmental commitments</h2> <p>This year鈥檚 event will also see a landmark moment in Boat Race history. Sarah Winckless MBE will become the first woman to umpire the Men鈥檚 Boat Race on the Championship Course. Sir Matthew Pinsent CBE will oversee the Women鈥檚 Boat Race.</p> <p>Additionally, 探花直播Boat Race Company, alongside the Cambridge and Oxford 探花直播 Boat Clubs, have given their support to the London Rivers鈥 Pledge, a 10-year environmental initiative focused on improving water quality and sustainability on the Thames and beyond.</p> <p>With the crews now announced and excitement continuing to build, all eyes will be on the Thames this April as Cambridge and Oxford prepare to write the next chapter in their historic rivalry.<br /> 聽</p> </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p> 探花直播stage has been set for 探花直播Boat Race 2025, with Cambridge 探花直播 Boat Club announcing its Women鈥檚 and Men鈥檚 Blue Boats at the historic Battersea Power Station in London.</p> </p></div></div></div><div class="field field-name-field-image-credit field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://row-360.com/" target="_blank">Row360</a></div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img alt="Creative Commons License." src="/sites/www.cam.ac.uk/files/inner-images/cc-by-nc-sa-4-license.png" style="border-width: 0px; width: 88px; height: 31px;" /></a><br /> 探花直播text in this work is licensed under a <a href="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways 鈥 on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p> </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Wed, 26 Mar 2025 18:00:00 +0000 hcf38 248812 at Vice-Chancellor continues UK tour /news/vice-chancellor-continues-uk-tour-south-west-england <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/news/news-deborah-prentice-south-west-priory-community-school-worle-885x432.jpg?itok=4T8jS_bM" alt=" 探花直播Vice-Chancellor at Priory Community School, Worle." title="Credit: None" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> 探花直播South West of England has one of the country鈥檚 lowest levels of student progression into higher education. One of the key objectives of the visit was to engage with pupils and teachers in an area that is conspicuously under-represented in applications and admissions to Cambridge.</p> <p>First stop was Colyton Grammar School, in east Devon, where Professor Prentice talked to school leaders about the barriers encountered by students from the region wishing to attend university. Joining her were representatives from Downing College, which has a particular connection to the area. They were also joined by Mike Nicholson, the 探花直播鈥檚 Director of Recruitment, Admissions and Participation, and Tom Levinson, Head of Widening Participation and Collaborative Outreach.</p> <p> 探花直播 探花直播 of Cambridge and Downing College have partnered with the 探花直播 of Bristol and the Sutton Trust to support the Colyton Foundation Your Future Story 鈥 a programme that aims to support high attaining students from under-resourced backgrounds in the South West to pursue higher education opportunities.</p> <p>In the evening, the Vice-Chancellor attended a reception in Bristol which was attended by nearly 50 Cambridge alumni, including one who matriculated in 1949.</p> <p> 探花直播following day the Vice-Chancellor travelled to North Somerset for a visit to Priory Community School, part of an Academy Trust in Worle, near Weston-super-Mare. Mike Nicholson led a school assembly for year 11 students. Later that morning, Xanthe Robertson, Access and Recruitment Officer of Trinity Hall, Cambridge, led assemblies for 1,500 students in Years 7 through to 10.</p> <p> 探花直播Vice-Chancellor and colleagues were interviewed by members of a student news team named after the journalist Jill Dando, who grew up in Worle. 探花直播visitors noted that among the school鈥檚 notable alumni was Stephen Jenkins, Professor of Physical and Computational Surface Chemistry at Cambridge.</p> <p></p> <p> 探花直播next stop was Weston College, a further and higher education College in Weston-super-Mare that provides education and vocational training to students from the age of 14 through to adulthood. There the group met Sixth Form students to hear about their aspirations.</p> <p> 探花直播final leg of the journey took the Cambridge delegation to St Bede鈥檚 Catholic and Sixth Form College in Bristol. 探花直播school is part of the HE+ network, through which the 探花直播 of Cambridge and Colleges work together with schools FE establishments across the country to encourage applications from talented students.</p> <p>Reflecting on her visit, the Vice-Chancellor said: 鈥淭ravelling to the South West allowed me to learn more about the region and to understand some of the barriers to aspiration and attainment that prevent bright students from pursuing higher education. 探花直播students we met were impressive. Their teachers鈥 commitment to supporting their educational journey is outstanding. I hope that the outreach partnerships between the 探花直播, the Colleges and local schools will help us attract talented students to Cambridge, and will more generally encourage them to consider going to university.鈥</p> <p>This visit to the South West followed the Vice-Chancellor鈥檚 trip to Rochdale, Manchester and Liverpool a year ago and her visit to Peterborough in the autumn of 2024.</p> </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p> 探花直播Vice-Chancellor, Professor Deborah Prentice, has led a delegation to Devon, North Somerset and Bristol. It was the first time a serving Cambridge Vice-Chancellor had travelled聽to the region in an official capacity to engage with local schools and alumni.</p> </p></div></div></div><div class="field field-name-field-content-quote field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"> 探花直播students we met were impressive </div></div></div><div class="field field-name-field-content-quote-name field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Professor Deborah Prentice </div></div></div><div class="field field-name-field-slideshow field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/sites/default/files/debbieclass.jpg" title="Professor Prentice listening intently to students" class="colorbox" data-colorbox-gallery="" data-cbox-img-attrs="{&quot;title&quot;: &quot;Professor Prentice listening intently to students&quot;, &quot;alt&quot;: &quot;&quot;}"><img class="cam-scale-with-grid" src="/sites/default/files/styles/slideshow/public/debbieclass.jpg?itok=BMNa4IXl" width="590" height="288" alt="" title="Professor Prentice listening intently to students" /></a></div><div class="field-item odd"><a href="/sites/default/files/debbieweston.jpg" title="At Weston College " class="colorbox" data-colorbox-gallery="" data-cbox-img-attrs="{&quot;title&quot;: &quot;At Weston College &quot;, &quot;alt&quot;: &quot;&quot;}"><img class="cam-scale-with-grid" src="/sites/default/files/styles/slideshow/public/debbieweston.jpg?itok=dcHuoJKI" width="590" height="288" alt="" title="At Weston College " /></a></div><div class="field-item even"><a href="/sites/default/files/debbieteam2.jpg" title="With students from Priory Community School" class="colorbox" data-colorbox-gallery="" data-cbox-img-attrs="{&quot;title&quot;: &quot;With students from Priory Community School&quot;, &quot;alt&quot;: &quot;&quot;}"><img class="cam-scale-with-grid" src="/sites/default/files/styles/slideshow/public/debbieteam2.jpg?itok=FjV7sPuL" width="590" height="288" alt="" title="With students from Priory Community School" /></a></div><div class="field-item odd"><a href="/sites/default/files/debbieclass2.jpg" title="Professor Prentice back in the classroom" class="colorbox" data-colorbox-gallery="" data-cbox-img-attrs="{&quot;title&quot;: &quot;Professor Prentice back in the classroom&quot;, &quot;alt&quot;: &quot;&quot;}"><img class="cam-scale-with-grid" src="/sites/default/files/styles/slideshow/public/debbieclass2.jpg?itok=vvKXoMLu" width="590" height="288" alt="" title="Professor Prentice back in the classroom" /></a></div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img alt="Creative Commons License." src="/sites/www.cam.ac.uk/files/inner-images/cc-by-nc-sa-4-license.png" style="border-width: 0px; width: 88px; height: 31px;" /></a><br /> 探花直播text in this work is licensed under a <a href="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways 鈥 on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p> </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Mon, 17 Mar 2025 14:52:55 +0000 ps748 248779 at Exploding into life: Volcanic power erupts at Downing's Magma Rising exhibition /stories/magma-rising-exhibition-downing <div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>New exhibition 鈥 including works by Icelandic singer-songwriter Bj枚rk, filmmaker Werner Herzog, and Xbox Game Studio Ninja Theory 鈥撀爏howcases the awesome power of volcanoes.</p> </p></div></div></div> Wed, 26 Feb 2025 12:53:08 +0000 sb726 248728 at Mental Health Overhaul: probing the processes behind the symptoms /stories/mental-health-illness-research <div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>A new Cambridge network is turning to basic science in a bid to advance our understanding and treatment of mental health disorders</p> </p></div></div></div> Fri, 04 Oct 2024 08:43:46 +0000 jg533 248131 at A-level results day 2024 /stories/Alevels2024 <div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>Congratulations to the students who've achieved the grades they needed at A-level to secure a place on a degree course at Cambridge.聽</p> </p></div></div></div> Thu, 15 Aug 2024 16:47:51 +0000 hcf38 247441 at Study unpicks why childhood maltreatment continues to impact on mental and physical health into adulthood /research/news/study-unpicks-why-childhood-maltreatment-continues-to-impact-on-mental-and-physical-health-into <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/research/news/mali-desha-my-6bncc3rw-unsplash.jpg?itok=PJxww6HS" alt="Black and white image of boy curled up on the floor" title="Black and white image of boy curled up on the floor, Credit: mali desha (Unsplash)" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Individuals who experienced maltreatment in childhood 鈥 such as emotional, physical and sexual abuse, or emotional and physical neglect 鈥 are more likely to develop mental illness throughout their entire life, but it is not yet well understood why this risk persists many decades after maltreatment first took place.</p> <p>In a study published in Proceedings of the National Academy of Sciences, scientists from the 探花直播 of Cambridge and Leiden 探花直播 found that adult brains continue to be affected by childhood maltreatment in adulthood because these experiences make individuals more likely to experience obesity, inflammation and traumatic events, all of which are risk factors for poor health and wellbeing, which in turn also affect brain structure and therefore brain health.</p> <p> 探花直播researchers examined MRI brain scans from approximately 21,000 adult participants aged 40 to 70 years in UK Biobank, as well as information on body mass index (an indicator of metabolic health), CRP (a blood marker of inflammation) and experiences of childhood maltreatment and adult trauma.</p> <p>Sofia Orellana, a PhD student at the Department of Psychiatry and Darwin College, 探花直播 of Cambridge, said: 鈥淲e鈥檝e known for some time that people who experience abuse or neglect as a child can continue to experience mental health problems long into adulthood and that their experiences can also cause long term problems for the brain, the immune system and the metabolic system, which ultimately controls the health of your heart or your propensity to diabetes for instance. What hasn鈥檛 been clear is how all these effects interact or reinforce each other.鈥</p> <p>Using a type of statistical modelling that allowed them to determine how these interactions work, the researchers confirmed that experiencing childhood maltreatment made individuals more likely to have an increased body mass index (or obesity) and experience greater rates of trauma in adulthood. Individuals with a history of maltreatment tended to show signs of dysfunction in their immune systems, and the researchers showed that this dysfunction is the product of obesity and repeated exposure to traumatic events.</p> <p>Next, the researchers expanded their models to include MRI measures of the adult鈥檚 brains and were able to show that widespread increases and decreases in brain thickness and volume associated with greater body mass index, inflammation and trauma were attributable to childhood maltreatment having made these factors more likely in the first place. These changes in brain structure likely mean that some form of physical damage is occurring to brain cells, affecting how they work and function.</p> <p>Although there is more to do to understand how these effects operate at a cellular level in the brain, the researchers believe that their findings advance our understanding of how adverse events in childhood can contribute to life-long increased risk of brain and mind health disorders.</p> <p>Professor Ed Bullmore from the Department of Psychiatry, Cambridge, said: 鈥淣ow that we have a better understanding of why childhood maltreatment has long term effects, we can potentially look for biomarkers 鈥 biological red flags 鈥 that indicate whether an individual is at increased risk of continuing problems. This could help us target early on those who most need help, and hopefully aid them in breaking this chain of ill health.鈥</p> <p>Professor Bullmore is a Fellow at Lucy Cavendish College and聽and an Honorary Fellow at Downing College.</p> <p> 探花直播research was supported by MQ: Transforming Mental Health, the Royal Society, Medical Research Council, National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre, the NIHR Applied Research Collaboration East of England, Girton College and Darwin College.</p> <p><em><strong>Reference</strong><br /> Orellana, SC et al. <a href="https://www.pnas.org/doi/10.1073/pnas.2304704121">Childhood maltreatment influences adult brain structure through its effects on immune, metabolic and psychosocial factors.</a> PNAS; 9 Apr 2024 ; DOI: 10.1073/pnas.230470412</em></p> </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>Childhood maltreatment can continue to have an impact long into adulthood because of how it effects an individual鈥檚 risk of poor physical health and traumatic experiences many years later, a new study has found.</p> </p></div></div></div><div class="field field-name-field-content-quote field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even">We鈥檝e known for some time that people who experience abuse or neglect as a child can continue to experience mental health problems long into adulthood</div></div></div><div class="field field-name-field-content-quote-name field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Sofia Orellana</div></div></div><div class="field field-name-field-image-credit field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://unsplash.com/photos/man-in-black-jacket-and-pants-sitting-on-stairs-mY-6bncc3rw" target="_blank">mali desha (Unsplash)</a></div></div></div><div class="field field-name-field-image-desctiprion field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Black and white image of boy curled up on the floor</div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img alt="Creative Commons License." src="/sites/www.cam.ac.uk/files/inner-images/cc-by-nc-sa-4-license.png" style="border-width: 0px; width: 88px; height: 31px;" /></a><br /> 探花直播text in this work is licensed under a <a href="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways 鈥 on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p> </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div><div class="field field-name-field-license-type field-type-taxonomy-term-reference field-label-above"><div class="field-label">Licence type:&nbsp;</div><div class="field-items"><div class="field-item even"><a href="/taxonomy/imagecredit/public-domain">Public Domain</a></div></div></div> Thu, 11 Apr 2024 14:31:51 +0000 cjb250 245631 at Reduced grey matter in frontal lobes linked to teenage smoking and nicotine addiction /research/news/reduced-grey-matter-in-frontal-lobes-linked-to-teenage-smoking-and-nicotine-addiction-study <div class="field field-name-field-news-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img class="cam-scale-with-grid" src="/sites/default/files/styles/content-580x288/public/news/research/news/smoking_0.jpg?itok=WFfUd6xn" alt="Young people smoking " title="Young people smoking , Credit: None" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Levels of grey matter in two parts of the brain may be linked to a desire to start smoking during adolescence and the strengthening of nicotine addiction, a new study has shown.</p>&#13; &#13; <p>A team of scientists, led by the universities of Cambridge and Warwick in the UK and Fudan 探花直播 in China, analysed brain imaging and behavioural data of over 800 young people at the ages of 14, 19 and 23.</p>&#13; &#13; <p>They found that, on average, teenagers who started smoking by 14 years of age had markedly less grey matter in a section of the left frontal lobe linked to decision-making and rule-breaking.聽</p>&#13; &#13; <p>Grey matter is the brain tissue that processes information, and contains all of the organ鈥檚 neurons. While brain development continues into adulthood, grey matter growth peaks before adolescence. 聽</p>&#13; &#13; <p>Low grey matter volume in the left side of the ventromedial prefrontal cortex may be an 鈥渋nheritable biomarker鈥 for nicotine addiction, say researchers 鈥 with implications for prevention and treatment.聽</p>&#13; &#13; <p>In addition, the scientists found that the opposite, right part of the same brain region also had less grey matter in smokers.</p>&#13; &#13; <p>Importantly, loss of grey matter in the right prefrontal cortex appears to speed up only after someone has started smoking. This region is linked to the seeking of sensations.</p>&#13; &#13; <p> 探花直播team argue that less grey matter in the left forebrain could lower cognitive function and lead to 鈥渄isinhibition鈥: impulsive, rule-breaking behaviour arising from a limited ability to consider consequences. This may increase the chances of smoking at a young age.</p>&#13; &#13; <p>Once a nicotine habit takes hold, grey matter in the right frontal lobe shrinks, which may weaken control over smoking by affecting 'hedonic motivation': the way pleasure is sought and managed. Excessive loss of grey matter in the right brain was also linked to binge drinking and marijuana use.聽</p>&#13; &#13; <p>Taken together, the findings point to a damaged 鈥渘eurobehavioural mechanism鈥 that can lead to nicotine use starting early and becoming locked into long-term addiction, say researchers. 探花直播study used data from the IMAGEN project and is <a href="https://www.nature.com/articles/s41467-023-40079-2">published in the journal <em>Nature Communications</em></a>.</p>&#13; &#13; <p>鈥淪moking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality,鈥 said Prof Trevor Robbins, co-senior author from Cambridge鈥檚 Department of Psychology.</p>&#13; &#13; <p>鈥 探花直播initiation of a smoking habit is most likely to occur during adolescence. Any way of detecting an increased chance of this, so we can target interventions, could help save millions of lives.鈥</p>&#13; &#13; <p>Annual deaths from cigarettes are expected to reach eight million worldwide by the end of the decade. Currently, one in five adult deaths each year are attributed to smoking in the US alone.</p>&#13; &#13; <p>鈥淚n our study, reduced grey matter in the left prefrontal cortex is associated with increased rule-breaking behaviour as well as early smoking experiences. It could be that this rule-breaking leads to the violation of anti-smoking norms,鈥 said Robbins.</p>&#13; &#13; <p>Co-author Prof Barbara Sahakian from Cambridge鈥檚 Department of Psychiatry said: 鈥 探花直播ventromedial prefrontal cortex is a key region for dopamine, the brain鈥檚 pleasure chemical. As well as a role in rewarding experiences, dopamine has long been believed to affect self-control.聽</p>&#13; &#13; <p>鈥淟ess grey matter across this brain region may limit cognitive function, leading to lower self-control and a propensity for risky behaviour, such as smoking.鈥</p>&#13; &#13; <p> 探花直播study used data gathered by the IMAGEN project from sites in four European countries: UK, Germany, France and Ireland. 探花直播researchers compared brain imaging data for those who had smoked by age 14 with those who had not, and repeated this for the same participants at ages 19 and 23.</p>&#13; &#13; <p>Those with smoking experience by 14 years of age had significantly less grey matter in the left prefrontal cortex, on average. Additionally, those who started smoking by age 19 also had less grey matter in their left prefrontal cortex at 14, indicating a potential causal influence.</p>&#13; &#13; <p> 探花直播scientists also looked at the right ventromedial prefrontal cortex. Grey matter loss occurs in everyone as they age. However, those who smoked from age 14 as well as those smoking from age 19 both ended up with excessive grey matter loss in the right frontal lobe.</p>&#13; &#13; <p>For the right prefrontal cortex, 19-year-old smokers who did not start during adolescence had similar grey matter levels at age 14 to those who never smoked at all. This suggests a rapid reduction in the right ventromedial prefrontal cortex only begins with the onset of smoking.</p>&#13; &#13; <p>Data at age 23 showed that grey matter volume in the right prefrontal cortex shrank at a faster pace in those who continued to smoke, suggesting an influence of smoking itself on prefrontal function.</p>&#13; &#13; <p>Researchers also analysed data from two questionnaires completed by participants to investigate the personality traits of novelty seeking and sensation seeking.</p>&#13; &#13; <p>鈥淏oth questionnaires examine the pursuit of thrilling experiences, but they measure distinct behaviours,鈥 said Robbins. 鈥 探花直播sensation seeking scale focuses on pleasurable experiences, while the novelty seeking questionnaire includes items on impulsiveness and rule-breaking.鈥</p>&#13; &#13; <p>Less grey matter in the left prefrontal cortex was associated with novelty seeking, particularly disorderly and rule-breaking behaviour, while reduced grey matter volume in the right prefrontal cortex was linked to sensation seeking only.</p>&#13; &#13; <p>Lead author Prof Tianye Jia from Fudan 探花直播 added: 鈥淟ess grey matter in the left frontal lobes is linked to behaviours that increase the likelihood of smoking in adolescence.</p>&#13; &#13; <p>鈥淪mokers then experience excessive loss of grey matter in the right frontal lobes, which is linked to behaviours that reinforce substance use. This may provide a causal account of how smoking is initiated in young people, and how it turns into dependence.鈥</p>&#13; &#13; <p><em><strong>Reference:</strong></em><br />&#13; <em>Jia, Tianye; Xiang, Shintong et al. <a href="https://www.nature.com/articles/s41467-023-40079-2">Association between vmPFC gray matter volume and smoking initiation in adolescents</a>. Nature Communications; 15 Aug 2023; DOI: 10.1038/s41467-023-40079-2</em></p>&#13; </div></div></div><div class="field field-name-field-content-summary field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><p>Findings may demonstrate a brain and behavioural basis for how nicotine addiction is initiated and then takes hold in early life, say scientists.聽</p>&#13; </p></div></div></div><div class="field field-name-field-content-quote field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even">Smoking is perhaps the most common addictive behaviour in the world, and a leading cause of adult mortality</div></div></div><div class="field field-name-field-content-quote-name field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Trevor Robbins</div></div></div><div class="field field-name-field-image-desctiprion field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Young people smoking </div></div></div><div class="field field-name-field-cc-attribute-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img alt="Creative Commons License." src="/sites/www.cam.ac.uk/files/inner-images/cc-by-nc-sa-4-license.png" style="border-width: 0px; width: 88px; height: 31px;" /></a><br />&#13; 探花直播text in this work is licensed under a <a href="https://creativecommons.org/licenses/by-nc-sa/4.0/">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. Images, including our videos, are Copyright 漏 探花直播 of Cambridge and licensors/contributors as identified.聽 All rights reserved. We make our image and video content available in a number of ways 鈥 as here, on our <a href="/">main website</a> under its <a href="/about-this-site/terms-and-conditions">Terms and conditions</a>, and on a <a href="/about-this-site/connect-with-us">range of channels including social media</a> that permit your use and sharing of our content under their respective Terms.</p>&#13; </div></div></div><div class="field field-name-field-show-cc-text field-type-list-boolean field-label-hidden"><div class="field-items"><div class="field-item even">Yes</div></div></div> Tue, 15 Aug 2023 15:02:04 +0000 fpjl2 241301 at